Nemonoxacin

Synonym(s): TG-873870 (Taigexyn)

Class: Quinolone

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Nemonoxacin (TG-873870) is a novel non-fluorinated quinolone with potent broad-spectrum activity against gram-positive, gram-negative, and atypical pathogens, including vancomycin-nonsusceptible methicillin-resistant Staphylococcus aureus (MRSA), quinolone-resistant MRSA, quinolone-resistant Streptococcus pneumoniae, penicillin-resistant S. pneumoniae, and erythromycin-resistant S. pneumoniae.
Description:	Cardiovascular Safety Evaluation of Nemonoxacin (TG-873870) in Dogs and Monkeys. . A-27. Abstr. 47th Intersci. Conf. Antimicrob. Agents Chemother. By: Chow, C. P.; Tsai, C. Y.; Chen, Y. M.
Institute where first reported:	TaiGen Biotechnology Co.,Taiwan
Year first mentioned:	2007
Development status:	Approved in Taiwan

Chemical structure(s):
Canonical SMILES:	C[C@H]1C[C@@H](CN(C1)C2=CC=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)N
Isomeric SMILES:	C[C@H]1C[C@@H](CN(C1)C2=C(C3=C(C=C2)C(=O)C(=CN3C4CC4)C(=O)O)OC)N
InChI:	InChI=1S/C20H25N3O4/c1-11-7-12(21)9-22(8-11)16-6-5-14-17(19(16)27-2)23(13-3-4-13)10-15(18(14)24)20(25)26/h5-6,10-13H,3-4,7-9,21H2,1-2H3,(H,25,26)/t11-,12-/m0/s1
InChI Key:	AVPQPGFLVZTJOR-RYUDHWBXSA-N

External links:
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/11993740
Guide to Pharmacology:	nemonoxacin
Main Source:	https://www.taiwan-healthcare.org/biotech/biotech-product?vendorSysid=BhsProducts20161115182506986696315
Citations:	http://aac.asm.org/content/57/7/2942.full http://aac.asm.org/content/58/10/6116.full https://www.ncbi.nlm.nih.gov/pubmed/25079302