Compound ID | 158

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Nemonoxacin

Synonym(s): TG-873870 (Taigexyn)

Class: Quinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor
Target Pathogen: Active against vancomycin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, quinolone-resistant Staphylococcus aureus, quinolone-resistant Streptococcus pneumoniae, penicillin-resistant Streptococcus pneumoniae, and erythromycin-resistant Streptococcus pneumoniae
Description: Synthetic compound; a novel non-fluorinated quinolone developed in oral and intravenous formulations; Cardiovascular Safety Evaluation of Nemonoxacin (TG-873870) in Dogs and Monkeys. . A-27. Abstr. 47th Intersci. Conf. Antimicrob. Agents Chemother. By: Chow, C. P.; Tsai, C. Y.; Chen, Y. M.
Institute where first reported: TaiGen Biotechnology Co.,Taiwan
Year first mentioned: 2007
Highest development stage: Approved in Taiwan
Development status: Approved
Chemical structure(s):
Click here for structure editor
Molecular weight: 371.43
Iso. SMILES: C[C@H]1C[C@@H](CN(C1)C2=C(C3=C(C=C2)C(=O)C(=CN3C4CC4)C(=O)O)OC)N
InChI Key: AVPQPGFLVZTJOR-RYUDHWBXSA-N
Can. SMILES: C[C@H]1C[C@@H](CN(C1)C2=CC=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)N
InChI: InChI=1S/C20H25N3O4/c1-11-7-12(21)9-22(8-11)16-6-5-14-17(19(16)27-2)23(13-3-4-13)10-15(18(14)24)20(25)26/h5-6,10-13H,3-4,7-9,21H2,1-2H3,(H,25,26)/t11-,12-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11993740
Guide to Pharmacology: nemonoxacin
Citations:
  • http://aac.asm.org/content/57/7/2942.full
  • http://aac.asm.org/content/58/10/6116.full
  • https://www.ncbi.nlm.nih.gov/pubmed/25079302
  • https://www.taiwan-healthcare.org/biotech/biotech-product?vendorSysid=BhsProducts20161115182506986696315

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