Compound ID | 1580

Update compound information

NPS-2143 derivative 29

Class: CaSR antagonist

Spectrum of activity: Gram-positive
Details of activity: Antimicrobial activity against Staphylococcus aureus and MRSA
Institute where first reported: Department of Medicinal Chemistry, Chengdu, China
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
Click here for structure editor
Molecular weight: 402.53
Iso. SMILES: O[C@H](CNC(C)(C)CC1=CC=C2C=CC=CC2=C1)COC3=C(C)C=C(C#N)C=C3C
InChI Key: SMFYFSJFORPQGN-XMMPIXPASA-N
Can. SMILES: CC1=C(C(=CC(=C1)C#N)C)OC[C@@H](CNC(C)(C)CC2=CC3=C(C=CC=C3)C=C2)O
InChI: InChI=1S/C26H30N2O2/c1-18-11-21(15-27)12-19(2)25(18)30-17-24(29)16-28-26(3,4)14-20-9-10-22-7-5-6-8-23(22)13-20/h5-13,24,28-29H,14,16-17H2,1-4H3/t24-/m1/s1
External links:
Citation: https://www.nature.com/articles/s41429-019-0177-9

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.