Compound ID | 1581

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NPS-2143 derivative 30

Class: CaSR antagonist

Spectrum of activity: Gram-positive
Details of activity: Antimicrobial activity against Staphylococcus aureus and MRSA
Institute where first reported: Department of Medicinal Chemistry, Chengdu, China
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 485.46
Iso. SMILES: O[C@H](CNC(C)(C)CC1=CC=C2C=CC=CC2=C1)COC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3
InChI Key: FRGZLSZYHLXLOQ-OAQYLSRUSA-N
Can. SMILES: CC(C)(CC1=CC2=C(C=CC=C2)C=C1)NC[C@H](COC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)O
InChI: InChI=1S/C25H25F6NO2/c1-23(2,13-16-7-8-17-5-3-4-6-18(17)9-16)32-14-21(33)15-34-22-11-19(24(26,27)28)10-20(12-22)25(29,30)31/h3-12,21,32-33H,13-15H2,1-2H3/t21-/m1/s1
External links:
Citation: https://www.nature.com/articles/s41429-019-0177-9

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