Compound ID | 160

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Colostrum Hexasaccharide

Class: Quorum-sensing inhibitor

Spectrum of activity: Gram-positive
Details of activity: This work for the first time explored interference with the cell-to-cell communication system of S. aureus, thereby demonstrating that CHS, a functional oligosaccharide of colostrum, suppresses expression of the virulence factors, degrades AHLs, prevents biofilm formation, and induces biofilm eradication.
Institute where first reported: Pharmacognosy & Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow, Uttar Pradesh, India
Year first mentioned: 1976 (for compound) 2015 (for research)
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 1112.04
Iso. SMILES: O[C@@H]1[C@H](O)[C@@H](NC(C)=O)[C@@H](O[C@H]2[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]3[C@@H](O[C@H]4[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O4)[C@@H](NC(C)=O)[C@H](OC[C@H]5O[C@@H](O[C@H]6[C@H](O)[C@@H](O)C(O)O[C@@H]6CO)[C@H](O)[C@@H](O)[C@H]5O)C[C@@H]3CO)[C@@H]2O)O[C@@H]1CO
InChI Key: ZXTDVHXHLLKOLI-RGQRNBBPSA-N
Can. SMILES: CC(=O)N[C@H]1[C@@H](C[C@H](CO)[C@H]([C@H]1O[C@H]2[C@@H]([C@H]([C@H]([C@@H](CO)O2)O)O)NC(=O)C)O[C@H]3[C@@H]([C@H]([C@H]([C@@H](CO)O3)O)O[C@@H]4[C@@H]([C@H]([C@H]([C@@H](CO)O4)O)O)NC(=O)C)O)OC[C@@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)O[C@@H]6[C@@H](CO)OC([C@@H]([C@H]6O)O)O)O)O)O
InChI: InChI=1S/C43H73N3O30/c1-11(52)44-21-15(67-10-20-26(57)30(61)33(64)42(72-20)74-36-19(9-51)68-39(66)32(63)31(36)62)4-14(5-47)35(37(21)75-40-22(45-12(2)53)28(59)24(55)16(6-48)69-40)73-43-34(65)38(27(58)18(8-50)71-43)76-41-23(46-13(3)54)29(60)25(56)17(7-49)70-41/h14-43,47-51,55-66H,4-10H2,1-3H3,(H,44,52)(H,45,53)(H,46,54)/t14-,15-,16-,17-,18-,19-,20-,21+,22-,23-,24+,25+,26+,27+,28-,29-,30+,31-,32-,33-,34-,35-,36-,37+,38+,39?,40+,41-,42+,43+/m1/s1
External links:
Citations:
  • http://aac.asm.org/content/59/4/2169.full
  • https://journals.asm.org/doi/full/10.1128/aac.03722-14

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