Compound ID | 164

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Delpazolid

Synonym(s): LCB01-0371

Class: Oxazolidinone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor. Binds to the 23S ribosomal RNA
Description: Synthetic compound containing cyclic amidrazone group which promotes excretion of compound; less toxic than linezolid due to its rapid clearance and reduced plasma accumulation
Institute where first reported: LegoChem Biosciences (South Korea)
Year first mentioned: 2010
Highest developmental phase: Phase 2 (NCT05225558; NCT06004037)
Development status: Active
Reason Dropped: NCT05225558 Clinical Trial terminated due to issues with enrolling subjects.
Chemical structure(s):
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Molecular weight: 308.31
Iso. SMILES: CN1CCN(C=N1)C2=C(C=C(C=C2)N3C[C@@H](OC3=O)CO)F
InChI Key: QLUWQAFDTNAYPN-LLVKDONJSA-N
Can. SMILES: CN1CCN(C=N1)C2=CC=C(C=C2F)N3C[C@H](CO)OC3=O
InChI: InChI=1S/C14H17FN4O3/c1-17-4-5-18(9-16-17)13-3-2-10(6-12(13)15)19-7-11(8-20)22-14(19)21/h2-3,6,9,11,20H,4-5,7-8H2,1H3/t11-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/44205191
Guide to Pharmacology: delpazolid
Citations:
  • http://aac.asm.org/content/54/12/5359.full
  • https://www.researchgate.net/publication/325198402_Delpazolid_Oxazolidinone_antibiotic_Treatment_of_tuberculosis
  • http://www.legochembio.com/m/eng/board_skin/board_view.asp?idx=406&page=1&bbs_code=13&key=0&word=&etc=

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