Compound ID | 165

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Contezolid

Synonym(s): MRX-4/MRX-1

Class: Oxazolidinone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus sp. ABSSI infections
Institute where first reported: MicuRx Pharmaceuticals, USA
Year first mentioned: 2014
Highest developmental phase: Approved in China in 2021
Development status: Approved
Chemical structure(s):
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Molecular weight: 408.33
Iso. SMILES: C1CN(C=CC1=O)C2=C(C=C(C(=C2F)F)N3C[C@@H](OC3=O)CNC4=NOC=C4)F
InChI Key: SULYVXZZUMRQAX-NSHDSACASA-N
Can. SMILES: C1=CN(CCC1=O)C2=C(C=C(C(=C2F)F)N3C[C@H](CNC4=NOC=C4)OC3=O)F
InChI: InChI=1S/C18H15F3N4O4/c19-12-7-13(15(20)16(21)17(12)24-4-1-10(26)2-5-24)25-9-11(29-18(25)27)8-22-14-3-6-28-23-14/h1,3-4,6-7,11H,2,5,8-9H2,(H,22,23)/t11-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/25184541
Guide to Pharmacology: contezolid
Citations:
  • http://aac.asm.org/content/58/4/2418.full
  • https://www.newtbdrugs.org/pipeline/compound/contezolid-mrx-4mrx-1

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