Tedizolid (Sivextro)

Synonym(s): Torezolid

Class: Oxazolidinone

Spectrum of activity:	Gram-positive
Details of activity:	Approved for: acute bacterial skin and skin structure infections; other potential indications: hospital-acquired bacterial pneumonia/ventilator-acquired bacterial pneumonia
Institute where first reported:	Cubist Pharmaceuticals; (Merck) USA
Year first mentioned:	2007
Highest developmental phase:	Approved by FDA in 2014
Development status:	Approved

Chemical structure(s):
Canonical SMILES:	CN1N=C(C2=NC=C(C=C2)C3=C(C=C(C=C3)N4C[C@H](CO)OC4=O)F)N=N1
Isomeric SMILES:	CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4C[C@@H](OC4=O)CO)F
InChI:	InChI=1S/C17H15FN6O3/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(9-25)27-17(24)26/h2-7,12,25H,8-9H2,1H3/t12-/m1/s1
InChI Key:	XFALPSLJIHVRKE-GFCCVEGCSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/11234049

External links:
Guide to Pharmacology:	tedizolid
Citations:	http://aac.asm.org/content/53/8/3236.full http://aac.asm.org/content/57/6/2892.full http://aac.asm.org/content/57/7/3060.full