Compound ID | 167

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Tedizolid (Sivextro)

Synonym(s): Torezolid

Class: Oxazolidinone

Spectrum of activity: Gram-positive
Details of activity: Approved for: acute bacterial skin and skin structure infections; other potential indications: hospital-acquired bacterial pneumonia/ventilator-acquired bacterial pneumonia
Institute where first reported: Cubist Pharmaceuticals; (Merck) USA
Year first mentioned: 2007
Highest developmental phase: Approved by FDA in 2014
Development status: Approved
Chemical structure(s):
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Molecular weight: 370.34
Iso. SMILES: CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4C[C@@H](OC4=O)CO)F
InChI Key: XFALPSLJIHVRKE-GFCCVEGCSA-N
Can. SMILES: CN1N=C(C2=NC=C(C=C2)C3=C(C=C(C=C3)N4C[C@H](CO)OC4=O)F)N=N1
InChI: InChI=1S/C17H15FN6O3/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(9-25)27-17(24)26/h2-7,12,25H,8-9H2,1H3/t12-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11234049
Guide to Pharmacology: tedizolid
Citations:
  • http://aac.asm.org/content/53/8/3236.full
  • http://aac.asm.org/content/57/6/2892.full
  • http://aac.asm.org/content/57/7/3060.full

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