Compound ID | 1690

Update compound information

G0775

Class: Small molecule antibacterial agent

Agent Type: Semisynthetic; Small molecule;
Spectrum of activity: Gram-negative
Mechanism of action: Type I signal peptidase inhibitor
Institute where first reported: Department of Infectious Diseases, San Francisco, USA
Year first mentioned: 2018
Highest development stage: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 890.04
Iso. SMILES: C[C@H]1C(=O)N[C@@H](CC2=CC(=C(C=C2)OCCN)C3=C(C=CC(=C3)[C@@H](C(=O)N1)N(C)C(=O)[C@H](CCN)NC(=O)C4=CN=C(N=C4C)C5=CC=C(C=C5)C(C)(C)C)OCCN)C(=O)NCC#N
InChI Key: FNOKZRYCHPSURW-WFXFPESJSA-N
Can. SMILES: CC1=C(C=NC(=N1)C2=CC=C(C=C2)C(C)(C)C)C(=O)N[C@@H](CCN)C(=O)N(C)[C@H]3C4=CC(=C(C=C4)OCCN)C5=CC(=CC=C5OCCN)C[C@@H](C(=O)NCC#N)NC(=O)[C@H](C)NC3=O
InChI: InChI=1S/C47H59N11O7/c1-27-35(26-53-41(54-27)30-8-11-32(12-9-30)47(3,4)5)43(60)56-36(15-16-48)46(63)58(6)40-31-10-14-39(65-22-19-51)34(25-31)33-23-29(7-13-38(33)64-21-18-50)24-37(44(61)52-20-17-49)57-42(59)28(2)55-45(40)62/h7-14,23,25-26,28,36-37,40H,15-16,18-22,24,48,50-51H2,1-6H3,(H,52,61)(H,55,62)(H,56,60)(H,57,59)/t28-,36-,37-,40-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/134827876
Guide to Pharmacology: G0775
Citation: https://www.nature.com/articles/s41586-018-0483-6

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