Compound ID | 1727

Update compound information

4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 18

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent
Target Pathogen: Active against Staphylococcus aureus
Description: Naphthyl-substituted pyrazole-derived hydrazone
Institute where first reported: Arkansas State University, Arkansas
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 511.37
Iso. SMILES: OC(C=1C=CC(=CC1)N2C=C(/C=N/NC3=CC=C(Br)C=C3)C(=N2)C4=CC5=CC=CC=C5C=C4)=O
InChI Key: JJVVSGMPTDRVKD-MUFRIFMGSA-N
Can. SMILES: C1=CC2=C(C=C1)C=C(C=C2)C3=NN(C=C3/C=N/NC4=CC=C(C=C4)Br)C5=CC=C(C=C5)C(=O)O
InChI: InChI=1S/C27H19BrN4O2/c28-23-9-11-24(12-10-23)30-29-16-22-17-32(25-13-7-19(8-14-25)27(33)34)31-26(22)21-6-5-18-3-1-2-4-20(18)15-21/h1-17,30H,(H,33,34)/b29-16+
External links:
Citation: https://www.nature.com/articles/s41429-020-0341-2

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