Compound ID | 1733

Update compound information

4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 24

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent
Target Pathogen: Active against Staphylococcus aureus
Description: Naphthyl-substituted pyrazole-derived hydrazone
Institute where first reported: Arkansas State University, Arkansas
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 522.43
Iso. SMILES: OC(C=1C=CC(=CC1)N2C=C(/C=N/NC3=C(F)C(F)=C(F)C(F)=C3F)C(=N2)C4=CC5=CC=CC=C5C=C4)=O
InChI Key: PDLYTWUQHXIVQD-RVDKCFQWSA-N
Can. SMILES: C1=CC2=C(C=C1)C=C(C=C2)C3=NN(C=C3/C=N/NC4=C(C(=C(C(=C4F)F)F)F)F)C5=CC=C(C=C5)C(=O)O
InChI: InChI=1S/C27H15F5N4O2/c28-20-21(29)23(31)26(24(32)22(20)30)34-33-12-18-13-36(19-9-7-15(8-10-19)27(37)38)35-25(18)17-6-5-14-3-1-2-4-16(14)11-17/h1-13,34H,(H,37,38)/b33-12+
External links:
Citation: https://www.nature.com/articles/s41429-020-0341-2

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