Clofoctol

Class: PqsR inhibitor

Spectrum of activity:	Gram-negative
Details of activity:	Active against P.aeruginosa
Year first mentioned:	1981
Highest developmental phase:	Preclinical

Chemical structure(s):
Canonical SMILES:	CC(C)(C)CC(C)(C)C1=CC=C(C(=C1)CC2=CC=C(C=C2Cl)Cl)O
Isomeric SMILES:	CC(C)(C)CC(C)(C)C1=CC(=C(C=C1)O)CC2=C(C=C(C=C2)Cl)Cl
InChI:	InChI=1S/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3
InChI Key:	HQVZOORKDNCGCK-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/2799

External links:
Guide to Pharmacology:	clofoctol
Main Source:	https://pubmed.ncbi.nlm.nih.gov/7154664/
Citations:	https://www.nature.com/articles/s41429-020-0344-zenter paper URL to add https://journals.asm.org/doi/10.1128/aac.01296-18