Compound ID | 1760

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Clofoctol

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting; Antivirulence;
Spectrum of activity: Gram-negative
Mechanism of action: PqsR inhibitor
Target Pathogen: Active against Pseudomonas aeruginosa
Year first mentioned: 1981
Highest development stage: Approved
Development status: Approved
Chemical structure(s):
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Molecular weight: 365.34
Iso. SMILES: CC(C)(C)CC(C)(C)C1=CC(=C(C=C1)O)CC2=C(C=C(C=C2)Cl)Cl
InChI Key: HQVZOORKDNCGCK-UHFFFAOYSA-N
Can. SMILES: CC(C)(C)CC(C)(C)C1=CC=C(C(=C1)CC2=CC=C(C=C2Cl)Cl)O
InChI: InChI=1S/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/2799
Guide to Pharmacology: clofoctol
Citations:
  • https://www.nature.com/articles/s41429-020-0344-zenter paper URL to add
  • https://journals.asm.org/doi/10.1128/aac.01296-18
  • https://pubmed.ncbi.nlm.nih.gov/7154664/

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