Compound ID | 1776

Update compound information

SMT-738

Synonym(s): DDS-04 series  |  SMT-026738

Spectrum of activity: Gram-negative
Details of activity: Active against Enterobacteriaceae. Inhibits the LolCDE pathway, an essential lipid transport system in Gram-negative bacteria
Description: Synthetic compound (genome profiling technology)
Institute where first reported: Summit Therapeutics
Year first mentioned: 2020
Highest development stage: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 392.46
Iso. SMILES: CC1=C(C=CN=C1)C2=C(N=C(N2)N)C3=CC4=C(C=C3)OCCN4C(=O)C(C)(C)N
InChI Key: JPOVQSBUKRMDME-UHFFFAOYSA-N
Can. SMILES: CC1=C(C=CN=C1)C2=C(C3=CC=C4C(=C3)N(CCO4)C(=O)C(C)(C)N)N=C(N)N2
InChI: InChI=1S/C21H24N6O2/c1-12-11-24-7-6-14(12)18-17(25-20(22)26-18)13-4-5-16-15(10-13)27(8-9-29-16)19(28)21(2,3)23/h4-7,10-11H,8-9,23H2,1-3H3,(H3,22,25,26)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/166107891
Guide to Pharmacology: SMT-738
Citation: https://www.summittxinc.com/our-programmes/enterobacteriaceae/

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