Compound ID | 1785

MET-X

Class: Beta-lactamase inhibitor

Agent Type: Direct acting; Antibiotic adjuvant;
Spectrum of activity: Gram-negative
Mechanism of action: Inhibits metallo-beta-lactamases which hydrolyse carbapenems
Target Pathogen: Active against Escherichia coli and Klebsiella pneumoniae
Combined with other compounds:
Description: Producing metallo-β-lactamase is just one reason for resistance to carbapenems; these enzymes are still uncommon in most high-income countries;only for use in combination with a carbapenem
Institute where first reported: Infex Therapeutics (formerly AMR Center), Medivir
Year first mentioned: 2022
Highest development stage: Preclinical
Development status: Experimental

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