Compound ID | 1797

Update compound information

LasB inhibitor

Class: Antivirulence agent

Agent Type: Synthetic; Small molecule; Direct acting; Antivirulence;
Spectrum of activity: Gram-negative
Mechanism of action: LasB inhibitor; elastase inhibitor
Target Pathogen: Active against Pseudomonas aeruginosa
Combined with other compounds: Yes
Description: Synthetic compound; received CARB-X funding; contains mercaptoacetamide scaffold
Institute where first reported: Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 271.38
Iso. SMILES: CC1=CC=C(NC(C(CC2=CC=CC=C2)S)=O)C=C1
InChI Key: JGIIFAFCJUOPQE-UHFFFAOYSA-N
Can. SMILES: CC1=CC=C(C=C1)NC(=O)C(CC2=CC=CC=C2)S
InChI: InChI=1S/C16H17NOS/c1-12-7-9-14(10-8-12)17-16(18)15(19)11-13-5-3-2-4-6-13/h2-10,15,19H,11H2,1H3,(H,17,18)
External links:
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/34762767/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429951/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112332/
  • https://www.helmholtz-hzi.de/en/research/research-topics/anti-infectives/drug-design-and-optimization/our-research/
    • Patent: WO2022043322

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