Compound ID | 1799

Update compound information

Cystobactamid

Class: Bacterial topoisomerase inhibitor

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Enterobacteriaceae and Acinetobacter. New chemical class as potential alternative to fluoroquinolones
Description: Natural compound. Non-ribosomally synthesized peptide antibiotics produced by different myxobacteria
Institute where first reported: Myxobiotics (Helmholtz Institute for Pharmaceutical Research Saarland), Evotec
Year first mentioned: 2019
Highest developmental phase: Preclinical
Development status: Active (as of 2022)
Chemical structure(s):
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Molecular weight: 507.54
Iso. SMILES: CC(C)OC1=C(C=CC(=C1)C(=O)O)NC(=O)C2=C(C(=C(C=C2)NC(=O)C3=CC=C(C=C3)N)OC(C)C)O
InChI Key: NUEKUSNLADIYQR-UHFFFAOYSA-N
Can. SMILES: CC(C)OC1=CC(=CC=C1NC(=O)C2=CC=C(C(=C2O)OC(C)C)NC(=O)C3=CC=C(C=C3)N)C(=O)O
InChI: InChI=1S/C27H29N3O7/c1-14(2)36-22-13-17(27(34)35)7-11-20(22)29-26(33)19-10-12-21(24(23(19)31)37-15(3)4)30-25(32)16-5-8-18(28)9-6-16/h5-15,31H,28H2,1-4H3,(H,29,33)(H,30,32)(H,34,35)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/90646593
Citations:
  • https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202000117
  • https://journals.asm.org/doi/10.1128/mSystems.00610-21
  • https://pubs.rsc.org/en/content/articlehtml/2020/sc/c9sc04769g
  • https://pubmed.ncbi.nlm.nih.gov/25510965/

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