Compound ID | 1810

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Globomycin

Class: Lipopeptide

Spectrum of activity: Gram-positive & Gram-negative
Details of activity: Inhibits signal peptidase II (LspA), an enzyme involved in lipoprotein posttranslational processing in bacteria
Description: Streptomyces natural product. Globomycin semisynthetic analog G0790
Institute where first reported: Sankyo Co
Year first mentioned: 1978
Highest development stage: Preclinical
Development status: Inactive (as of 2022)
Chemical structure(s):
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Molecular weight: 655.82
Iso. SMILES: CCCCCCC1C(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)O1)C(C)O)CO)C(C)CC)CC(C)C)C)C
InChI Key: VFGBXFZXJAWPOE-UHFFFAOYSA-N
Can. SMILES: CCCCCCC1C(C)C(=O)N(C)C(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NCC(=O)O1
InChI: InChI=1S/C32H57N5O9/c1-9-11-12-13-14-24-20(6)32(45)37(8)23(15-18(3)4)29(42)35-26(19(5)10-2)31(44)34-22(17-38)28(41)36-27(21(7)39)30(43)33-16-25(40)46-24/h18-24,26-27,38-39H,9-17H2,1-8H3,(H,33,43)(H,34,44)(H,35,42)(H,36,41)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/115071
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/14723954/
  • https://www.nature.com/articles/s41467-019-13724-y
  • https://www.science.org/doi/10.1126/science.aad3747
  • https://www.jstage.jst.go.jp/article/antibiotics1968/31/5/31_5_421/_article

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