Compound ID | 1811

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Myxovirescin

Class: Macrocyclic antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Inhibits signal peptidase II (LspA), an enzyme involved in lipoprotein posttranslational processing in bacteria
Description: Myxobacterium natural product
Institute where first reported: Helmholtz Institute for Pharmaceutical Research Saarland
Year first mentioned: 1982
Highest developmental phase: Preclinical
Development status: Active (as of 2022)
Chemical structure(s):
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Molecular weight: 623.86
Iso. SMILES: CCCC1C(=O)NCC(CC(C(CC/C(=C\C=CC(CCCC(=O)CCCCC(CC(C(=O)O1)C)C)CC)/COC)O)O)O
InChI Key: VQWNGCSUNKJFLW-AULPGBDISA-N
Can. SMILES: CCCC1C(=O)NCC(CC(C(CC/C(=C\C=CC(CC)CCCC(=O)CCCCC(C)CC(C)C(=O)O1)/COC)O)O)O
InChI: InChI=1S/C35H61NO8/c1-6-12-33-34(41)36-23-30(38)22-32(40)31(39)20-19-28(24-43-5)16-10-14-27(7-2)15-11-18-29(37)17-9-8-13-25(3)21-26(4)35(42)44-33/h10,14,16,25-27,30-33,38-40H,6-9,11-13,15,17-24H2,1-5H3,(H,36,41)/b14-10?,28-16+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6438547
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/35/11/35_11_1454/_pdf
  • https://www.nature.com/articles/s41467-019-13724-y
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318312/
  • https://pubs.rsc.org/en/content/articlelanding/1982/c3/c39820001340

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