Compound ID | 1812

Update compound information

G0507

Class: Pyrrolopyrimidinedione

Spectrum of activity: Gram-negative
Details of activity: Inhibits the LolCDE ABC transport machinery, which ensures proper trafficking of lipoproteins from the inner to the outer membrane
Description: Synthetic compound
Institute where first reported: Genentech
Year first mentioned: 2018
Highest developmental phase: Preclinical
Development status: Active (as of 2022)
Chemical structure(s):
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Molecular weight: 353.4
Iso. SMILES: CC1=CC=C(S1)C2=C(C3=C(N2)NC(=O)NC3=O)C4=CC=C(C=C4)OC
InChI Key: GZLHQRURTUJCHZ-UHFFFAOYSA-N
Can. SMILES: CC1=CC=C(C2=C(C3=CC=C(C=C3)OC)C4=C(N2)NC(=O)NC4=O)S1
InChI: InChI=1S/C18H15N3O3S/c1-9-3-8-12(25-9)15-13(10-4-6-11(24-2)7-5-10)14-16(19-15)20-18(23)21-17(14)22/h3-8H,1-2H3,(H3,19,20,21,22,23)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/50813566
Citations:
  • https://www.pnas.org/doi/10.1073/pnas.1806822115
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913989/

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