Compound ID | 1815

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CBR703

Class: RNA polymerase inhibitor (hydroxamidine)

Spectrum of activity: Gram-negative
Details of activity: Inhibits bacterial RNA polymerase in Enterobacteriaceae
Description: Synthetic compound
Institute where first reported: Cumbre Inc
Year first mentioned: 2003
Highest developmental phase: Preclinical
Development status: Inactive (as of 2022)
Chemical structure(s):
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Molecular weight: 280.25
Iso. SMILES: ON/C(/C1=CC=CC(C(F)(F)F)=C1)=N/C2=CC=CC=C2
InChI Key: SFPWZRCGYUTPNJ-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)/N=C(\C2=CC=CC(=C2)C(F)(F)F)/NO
InChI: InChI=1S/C14H11F3N2O/c15-14(16,17)11-6-4-5-10(9-11)13(19-20)18-12-7-2-1-3-8-12/h1-9,20H,(H,18,19)
External links:
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/14576436/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068539/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526357/

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