ETX0462

Class: Beta-lactamase inhibitor (diazabicyclooctane [DBO])

Spectrum of activity:	Gram-negative
Details of activity:	Inhibits PBP2 and is unaffected by β-lactamase mediated resistance. Active against Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii
Description:	Synthetic compound. Inhibitor of serine Beta-Lactamases
Institute where first reported:	Entasis Therapeutics
Year first mentioned:	2021
Highest developmental phase:	Preclinical
Development status:	Active (as of 2022)

Chemical structure(s):
Canonical SMILES:	CN=C([C@@H]1C2=C(C=NN2C)[C@H](CN1C(=O)O)NOS(=O)(=O)O)NO
Isomeric SMILES:	CN=C([C@@H]1C2=C(C=NN2C)[C@H](CN1C(=O)O)NOS(=O)(=O)O)NO
InChI:	InChI=1S/C10H16N6O7S/c1-11-9(13-19)8-7-5(3-12-15(7)2)6(4-16(8)10(17)18)14-23-24(20,21)22/h3,6,8,14,19H,4H2,1-2H3,(H,11,13)(H,17,18)(H,20,21,22)/t6-,8-/m0/s1
InChI Key:	TVYRNFNEBLNAMJ-XPUUQOCRSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/155920149

External links:
Guide to Pharmacology:	ETX0462
Main Source:	https://www.nature.com/articles/s41586-021-03899-0