Compound ID | 1820

Update compound information

ETX0462

Class: Beta-lactamase inhibitor

Agent Type: Synthetic; Small molecule; Direct acting; Antibiotic adjuvant;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. PBP2 inhibitor and unaffected by beta-lactamase mediated resistance
Target Pathogen: Active against Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii
Description: Synthetic compound; diazabicyclooctane (DBO) scaffold
Institute where first reported: Entasis Therapeutics
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
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Molecular weight: 364.34
Iso. SMILES: CN=C([C@@H]1C2=C(C=NN2C)[C@H](CN1C(=O)O)NOS(=O)(=O)O)NO
InChI Key: TVYRNFNEBLNAMJ-XPUUQOCRSA-N
Can. SMILES: CN=C([C@@H]1C2=C(C=NN2C)[C@H](CN1C(=O)O)NOS(=O)(=O)O)NO
InChI: InChI=1S/C10H16N6O7S/c1-11-9(13-19)8-7-5(3-12-15(7)2)6(4-16(8)10(17)18)14-23-24(20,21)22/h3,6,8,14,19H,4H2,1-2H3,(H,11,13)(H,17,18)(H,20,21,22)/t6-,8-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/155920149
Guide to Pharmacology: ETX0462
Citation: https://www.nature.com/articles/s41586-021-03899-0

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