Compound ID | 1821

Update compound information

ANT3310

Class: Beta-lactamase inhibitor

Agent Type: Synthetic; Small molecule; Direct acting; Antibiotic adjuvant;
Mechanism of action: Inhibits class A and C beta-lactamases; for use in combination with meropenem
Combined with other compounds: Yes
Description: Synthetic compound; diazabicyclooctane (DBO) scaffold
Institute where first reported: Antabio
Year first mentioned: 2020
Highest development stage: Phase 1 (NCT06916156)
Development status: Active
Chemical structure(s):
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Molecular weight: 262.19
Iso. SMILES: C1C[C@H](N2C[C@@H]1N(C2=O)OS(=O)(=O)[O-])F.[Na+]
InChI Key: UIJIKXQAJBMNIR-JBUOLDKXSA-M
Can. SMILES: C1C[C@@H](F)N2C[C@@H]1N(C2=O)OS(=O)(=O)[O-].[Na+]
InChI: InChI=1S/C6H9FN2O5S.Na/c7-5-2-1-4-3-8(5)6(10)9(4)14-15(11,12)13;/h4-5H,1-3H2,(H,11,12,13);/q;+1/p-1/t4-,5+;/m1./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/153516440
Guide to Pharmacology: ANT3310
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01535

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