Compound ID | 1822

Update compound information

ANT2681

Class: Beta-lactamase inhibitor (thiazole metallo beta-lactamase inhibitor )

Details of activity: Inhibits bacterial metallo ß-lactamase, especially NDM. Active against NDM carrying carbapenem-resistant Enterobacteriaceae
Combined with other compounds: Yes
Description: Synthetic compound. Combination with meropenem
Institute where first reported: Antabio
Year first mentioned: 2019
Highest developmental phase: Preclinical
Development status: Active (as of 2022)
Chemical structure(s):
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Molecular weight: 435.39
Iso. SMILES: C1=C(C=C(C(=C1F)NC(=O)NN=C(N)N)F)S(=O)(=O)NC2=C(N=CS2)C(=O)O
InChI Key: MDBJDQPFGYPCRJ-UHFFFAOYSA-N
Can. SMILES: C1=C(C(=C(C=C1S(=O)(=O)NC2=C(C(=O)O)N=CS2)F)NC(=O)NN=C(N)N)F
InChI: InChI=1S/C12H11F2N7O5S2/c13-5-1-4(2-6(14)7(5)18-12(24)20-19-11(15)16)28(25,26)21-9-8(10(22)23)17-3-27-9/h1-3,21H,(H,22,23)(H4,15,16,19)(H2,18,20,24)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/137422100
Citations:
  • https://pubs.acs.org/doi/10.1021/acs.accounts.0c00863
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315971/
  • https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00207

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