Compound ID | 1823

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MBX-4132

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Protein synthesis inhibitor. Inhibits trans-translation by binding to a unique site near the peptidyl-transfer centre and altering the conformation of ribosomal protein bL27
Target Pathogen: Active against Neisseria gonorrhoeae
Description: Synthetic compound
Institute where first reported: Microbiotix
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 338.34
Iso. SMILES: C1CN(CC2=CC=CC=C21)C(=O)NC3=NN=C(O3)C4=CC=C(C=C4)F
InChI Key: OZHWSOOZCIJFQN-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(C=C1)CN(CC2)C(=O)NC3=NN=C(C4=CC=C(C=C4)F)O3
InChI: InChI=1S/C18H15FN4O2/c19-15-7-5-13(6-8-15)16-21-22-17(25-16)20-18(24)23-10-9-12-3-1-2-4-14(12)11-23/h1-8H,9-11H2,(H,20,22,24)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/134691207
Guide to Pharmacology: MBX-4132
Citation: https://www.nature.com/articles/s41467-021-22012-7

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