Compound ID | 1828
GSK3882347
Class: Small molecule antibacterial agent
| Agent Type: | Synthetic; Small molecule; Direct acting; |
| Spectrum of activity: | Gram-negative |
| Mechanism of action: | Targets the adhesive protein in bacteria FimH and prevents adhesion of Escherichia coli to the bladder epithelial cells; FimH antagonist |
| Target Pathogen: | Active against Escherichia coli |
| Description: | Synthetic compound; mannose-containing small molecule |
| Institute where first reported: | GSK, Fimbrion Therapeutics |
| Year first mentioned: | 2020 |
| Highest development stage: | Phase 1 (NCT05760261) |
| Development status: | Active |
| External links: | |
| Citations: |
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