Compound ID | 1830

Update compound information

Corbomycin

Class: Glycopeptide

Spectrum of activity: Gram-positive
Details of activity: Inhibits the action of autolysins-essential peptidoglycan hydrolases that are required for remodelling of the cell wall during growth
Description: Natural compound
Institute where first reported: McMaster University, Ontario, Canada
Year first mentioned: 2020
Highest developmental phase: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1517.51
Iso. SMILES: CC(=O)NC(C1=CC=C(C=C1)[OH2+])C(=O)NC2C3=CC(=CC(=C3)OC4=C(C=CC(=C4)C5C(=O)NC6C7=CC(=C(C(=C7)OC8=CC=C(CC9C(=O)NC(C%10=C(C(=CC(=C%10)[OH2+])[OH2+])C%11=C(C=CC(=C%11)CC(C(=O)N9)NC6=O)[OH2+])C(=O)NC(C%12=CC(=CC(=C%12)[OH2+])[OH2+])C(=O)[OH2+])C=C8)[OH2+])C%13=CC%14=C(C=C%13)C(=CN%14)CC(C(=O)N5)NC2=O)[OH2+])[OH2+]
InChI Key: YPKFJNUZFFXJND-UHFFFAOYSA-X
Can. SMILES: CC(=O)NC(C1=CC=C(C=C1)[OH2+])C(=O)NC2C3=CC(=CC(=C3)[OH2+])OC4=CC(=CC=C4[OH2+])C5C(=O)NC6C7=CC(=C(C(=C7)OC8=CC=C(C=C8)CC9C(=O)NC(C%10=CC(=CC(=C%10C%11=CC(=CC=C%11[OH2+])CC(C(=O)N9)NC6=O)[OH2+])[OH2+])C(=O)NC(C%12=CC(=CC(=C%12)[OH2+])[OH2+])C(=O)[OH2+])[OH2+])C%13=CC%14=C(C=C%13)C(=CN%14)CC(C(=O)N5)NC2=O
InChI: InChI=1S/C79H66N10O22/c1-33(90)81-64(36-5-9-43(91)10-6-36)76(105)86-66-40-21-46(94)29-49(22-40)111-61-26-38(8-15-59(61)97)65-77(106)87-67-41-23-51(37-7-13-50-42(32-80-54(50)24-37)25-57(73(102)85-65)84-74(66)103)70(99)62(27-41)110-48-11-2-34(3-12-48)17-55-72(101)89-69(78(107)88-68(79(108)109)39-19-44(92)28-45(93)20-39)53-30-47(95)31-60(98)63(53)52-16-35(4-14-58(52)96)18-56(71(100)82-55)83-75(67)104/h2-16,19-24,26-32,55-57,64-69,80,91-99H,17-18,25H2,1H3,(H,81,90)(H,82,100)(H,83,104)(H,84,103)(H,85,102)(H,86,105)(H,87,106)(H,88,107)(H,89,101)(H,108,109)/p+10
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/162396890
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/32051588/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259425/
  • https://pubmed.ncbi.nlm.nih.gov/32051588/

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