Compound ID | 1831

Update compound information

Complestatin

Class: Glycopeptide

Spectrum of activity: Gram-positive
Details of activity: Inhibits the action of autolysins-essential peptidoglycan hydrolases that are required for remodelling of the cell wall during growth
Description: Natural compound
Institute where first reported: Sankyo Co
Year first mentioned: 1989
Highest developmental phase: Preclinical
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 1328.77
Iso. SMILES: CN1[C@@H](CC2=CC=C(C=C2)OC3=CC4=CC(=C3O)C5=CC6=C(C=C5)C(=CN6)C[C@@H](C(=O)N[C@H](C(=O)N[C@H]4C(=O)N[C@@H](C1=O)C7=CC(=C(C(=C7)Cl)O)Cl)C8=CC(=C(C(=C8)Cl)O)Cl)NC(=O)C(=O)C9=CC(=C(C(=C9)Cl)O)Cl)C(=O)N[C@H](C%10=CC=C(C=C%10)O)C(=O)O
InChI Key: JJGZGELTZPACID-NJFJLHGKSA-N
Can. SMILES: CN1[C@@H](CC2=CC=C(C=C2)OC3=CC4=CC(=C3O)C5=CC6=C(C=C5)C(=CN6)C[C@@H](C(=O)N[C@@H](C7=CC(=C(C(=C7)Cl)O)Cl)C(=O)N[C@H]4C(=O)N[C@H](C8=CC(=C(C(=C8)Cl)O)Cl)C1=O)NC(=O)C(=O)C9=CC(=C(C(=C9)Cl)O)Cl)C(=O)N[C@H](C%10=CC=C(C=C%10)O)C(=O)O
InChI: InChI=1S/C61H45Cl6N7O15/c1-74-44(56(82)73-49(61(87)88)25-4-7-32(75)8-5-25)12-24-2-9-33(10-3-24)89-45-22-27-13-35(51(45)77)26-6-11-34-31(23-68-42(34)20-26)21-43(69-59(85)50(76)30-18-40(66)54(80)41(67)19-30)55(81)70-47(28-14-36(62)52(78)37(63)15-28)57(83)71-46(27)58(84)72-48(60(74)86)29-16-38(64)53(79)39(65)17-29/h2-11,13-20,22-23,43-44,46-49,68,75,77-80H,12,21H2,1H3,(H,69,85)(H,70,81)(H,71,83)(H,72,84)(H,73,82)(H,87,88)/t43-,44-,46+,47-,48+,49+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/16129736
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259425/
  • https://pubmed.ncbi.nlm.nih.gov/2925515/

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.