Compound ID | 1835

Update compound information

Declovanillobiocin

Class: Aminocoumarin

Spectrum of activity: Gram-positive
Details of activity: Inhibits bacterial DNA gyrase via binding to the ATP-binding site of the GyrB subunit of the enzyme. Less active than clorobiocin
Propensity to select resistant mutants: Yes
Description: Streptomyces natural product; clorobiocin analog
Year first mentioned: 2004
Development status: Experimental
Chemical structure(s):
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Molecular weight: 624.59
Iso. SMILES: CC1=CC=C(N1)C(=O)OC2C(C(OC(C2OC)(C)C)OC3=CC4=C(C=C3)C(=C(C(=O)O4)NC(=O)C5=CC(=C(C=C5)O)OC)O)O
InChI Key: JURYCYSCKRZQLD-UHFFFAOYSA-N
Can. SMILES: CC1=CC=C(C(=O)OC2C(C(OC3=CC4=C(C=C3)C(=C(C(=O)O4)NC(=O)C5=CC=C(C(=C5)OC)O)O)OC(C)(C)C2OC)O)N1
InChI: InChI=1S/C31H32N2O12/c1-14-6-10-18(32-14)28(38)44-25-24(36)30(45-31(2,3)26(25)41-5)42-16-8-9-17-20(13-16)43-29(39)22(23(17)35)33-27(37)15-7-11-19(34)21(12-15)40-4/h6-13,24-26,30,32,34-36H,1-5H3,(H,33,37)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/76173558
Guide to Pharmacology: declovanillobiocin
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/57/3/57_3_205/_article

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