Gentamicin

Class: Aminoglycoside

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome. Active against Gram-positive and Gram-negative bacteria, mainly used against severe infections caused by Pseudomonas aeruginosa in combination
Description:	Micromonospora natural product. Available in parenteral, enteral (selective decontamination) and topical formulations; veterinary and human use
Year first mentioned:	1962
Highest developmental phase:	Approved by FDA in 1970
Development status:	Approved, off-patent
Reason Dropped:	Several formulations discontinued due to safety or effectiveness reasons

Chemical structure(s):
Canonical SMILES:	CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(C)(CO3)O)NC)O)N)N)N)NC
Isomeric SMILES:	CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC
InChI:	InChI=1S/C21H43N5O7/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20/h9-20,25-29H,5-8,22-24H2,1-4H3
InChI Key:	CEAZRRDELHUEMR-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/3467

External links:
Guide to Pharmacology:	gentamicin
Main Source:	https://go.drugbank.com/drugs/DB00798
Citations:	https://go.drugbank.com/drugs/DB00798 https://pubmed.ncbi.nlm.nih.gov/34711521/ https://pubmed.ncbi.nlm.nih.gov/35303195/