Spectinomycin

Class: Aminoglycoside

Spectrum of activity:	Gram-negative
Details of activity:	Inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome. Active against Gram-positive and Gram-negative bacteria
Description:	Streptomyces natural product. Veterinary use, rarely used in human medicine (e.g. Neisseria gonorrhoeae)
Year first mentioned:	1961
Highest developmental phase:	Approved by FDA in 1971
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	C[C@@H]1CC(=O)[C@]2([C@@H](O1)O[C@@H]3[C@H]([C@@H]([C@@H]([C@@H]([C@H]3O2)NC)O)NC)O)O
Isomeric SMILES:	C[C@@H]1CC(=O)[C@]2([C@@H](O1)O[C@@H]3[C@H]([C@@H]([C@@H]([C@@H]([C@H]3O2)NC)O)NC)O)O
InChI:	InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3/t5-,7-,8+,9+,10+,11-,12-,13+,14+/m1/s1
InChI Key:	UNFWWIHTNXNPBV-WXKVUWSESA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/15541

External links:
Guide to Pharmacology:	spectinomycin
Main Source:	https://pubmed.ncbi.nlm.nih.gov/13867836/