Dibekacin

Synonym(s): Debecacin

Class: Aminoglycoside

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome. Active against Gram-positive and Gram-negative bacteria
Description:	Semisynthetic, derived from kanamycin. Used for topical application
Institute where first reported:	Meiji Seika Pharma
Year first mentioned:	1975
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	C1C[C@H]([C@H](O[C@@H]1CN)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)N)O)N)N)N
Isomeric SMILES:	C1C[C@H]([C@H](O[C@@H]1CN)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N)N)N
InChI:	InChI=1S/C18H37N5O8/c19-4-6-1-2-7(20)17(28-6)30-15-8(21)3-9(22)16(14(15)27)31-18-13(26)11(23)12(25)10(5-24)29-18/h6-18,24-27H,1-5,19-23H2/t6-,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1
InChI Key:	JJCQSGDBDPYCEO-XVZSLQNASA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/470999

External links:
Guide to Pharmacology:	dibekacin
Main Source:	https://www.jstage.jst.go.jp/article/antibiotics1968/24/7/24_7_485/_article