Compound ID | 1847

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Dibekacin

Synonym(s): Debecacin

Class: Aminoglycoside

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome. Active against Gram-positive and Gram-negative bacteria
Description: Semisynthetic, derived from kanamycin. Used for topical application
Institute where first reported: Meiji Seika Pharma
Year first mentioned: 1975
Development status: Approved, off-patent
Chemical structure(s):
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Molecular weight: 451.52
Iso. SMILES: C1C[C@H]([C@H](O[C@@H]1CN)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N)N)N
InChI Key: JJCQSGDBDPYCEO-XVZSLQNASA-N
Can. SMILES: C1C[C@H]([C@H](O[C@@H]1CN)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)N)O)N)N)N
InChI: InChI=1S/C18H37N5O8/c19-4-6-1-2-7(20)17(28-6)30-15-8(21)3-9(22)16(14(15)27)31-18-13(26)11(23)12(25)10(5-24)29-18/h6-18,24-27H,1-5,19-23H2/t6-,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/470999
Guide to Pharmacology: dibekacin
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/24/7/24_7_485/_article

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