Netilmicin

Class: Aminoglycoside

Spectrum of activity:	Gram-negative
Details of activity:	Inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome. Active against Gram-negative bacteria
Description:	Semisynthetic, derived from sisomicin. Primarily used for topical application
Year first mentioned:	1973
Highest developmental phase:	Approved by FDA in 1983
Development status:	Discontinued
Reason Dropped:	Withdrawn (not marketed)

Chemical structure(s):
Canonical SMILES:	CCNC1CC(C(C(C1OC2C(C([C@](C)(CO2)O)NC)O)O)OC3C(CC=C(CN)O3)N)N
Isomeric SMILES:	CCNC1CC(C(C(C1OC2C(C([C@@](CO2)(C)O)NC)O)O)OC3C(CC=C(O3)CN)N)N
InChI:	InChI=1S/C21H41N5O7/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20/h5,11-20,25-29H,4,6-9,22-24H2,1-3H3/t11?,12?,13?,14?,15?,16?,17?,18?,19?,20?,21-/m0/s1
InChI Key:	CIDUJQMULVCIBT-BWFLUJJFSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/132062458

External links:
Guide to Pharmacology:	netilmicin
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595968/
Citations:	https://pubchem.ncbi.nlm.nih.gov/compound/41859 https://pubs.rsc.org/en/content/articlelanding/1976/c3/c39760000206