Compound ID | 1848

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Netilmicin

Class: Aminoglycoside

Spectrum of activity: Gram-negative
Details of activity: Inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome. Active against Gram-negative bacteria
Description: Semisynthetic, derived from sisomicin. Primarily used for topical application
Year first mentioned: 1973
Highest developmental phase: Approved by FDA in 1983
Development status: Discontinued
Reason Dropped: Withdrawn (not marketed)
Chemical structure(s):
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Molecular weight: 475.58
Iso. SMILES: CCNC1CC(C(C(C1OC2C(C([C@@](CO2)(C)O)NC)O)O)OC3C(CC=C(O3)CN)N)N
InChI Key: CIDUJQMULVCIBT-BWFLUJJFSA-N
Can. SMILES: CCNC1CC(C(C(C1OC2C(C([C@](C)(CO2)O)NC)O)O)OC3C(CC=C(CN)O3)N)N
InChI: InChI=1S/C21H41N5O7/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20/h5,11-20,25-29H,4,6-9,22-24H2,1-3H3/t11?,12?,13?,14?,15?,16?,17?,18?,19?,20?,21-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/132062458
Guide to Pharmacology: netilmicin
Citations:
  • https://pubchem.ncbi.nlm.nih.gov/compound/41859
  • https://pubs.rsc.org/en/content/articlelanding/1976/c3/c39760000206
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595968/

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