Paromomycin

Synonym(s): Monomycin  |  hydroxymycin

Class: Aminoglycoside

Spectrum of activity:	Gram-negative
Details of activity:	Inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome. Active against protozoa and some Gram-negative bacteria
Description:	Streptomyces natural product. Veterinary use, human use for the treatment of cryptosporidiosis, leishmaniasis, amoebiasis and cestodes, systemic and topical application
Year first mentioned:	1960
Highest developmental phase:	Approved by FDA in 1969
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)N)O[C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O[C@@H]4[C@@H]([C@H]([C@@H]([C@H](CN)O4)O)O)N)O)O)N.OS(=O)(=O)O
Isomeric SMILES:	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
InChI:	InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
InChI Key:	LJRDOKAZOAKLDU-UDXJMMFXSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/441375

External links:
Guide to Pharmacology:	paromomycin
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1967367/pdf/brmedj02912-0094.pdf
Citations:	https://dndi.org/wp-content/uploads/2009/06/VL_East%20Africa_2_Oct2010.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497224/