Ribostamycin

Synonym(s): Xylostatin  |  vistamycin

Class: Aminoglycoside

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome. Low activity against Gram-positive and Gram-negative bacteria
Description:	Streptomyces natural product
Year first mentioned:	1970
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@@H](CN)O2)O)O)N)O[C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O)O)O)N
Isomeric SMILES:	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)O)N
InChI:	InChI=1S/C17H34N4O10/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17/h4-17,22-27H,1-3,18-21H2/t4-,5+,6-,7-,8-,9+,10-,11-,12-,13-,14-,15-,16-,17+/m1/s1
InChI Key:	NSKGQURZWSPSBC-VVPCINPTSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/33042

External links:
Guide to Pharmacology:	ribostamycin
Main Source:	https://www.jstage.jst.go.jp/article/antibiotics1968/23/3/23_3_155/_article
Citation:	https://www.jstage.jst.go.jp/article/antibiotics1968/44/12/44_12_1357/_pdf