Compound ID | 1853

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Ribostamycin

Synonym(s): Xylostatin  |  vistamycin

Class: Aminoglycoside

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor. Binds to the bacterial 30S ribosomal subunit
Target Pathogen: Low activity against Gram-positive and Gram-negative bacteria
Description: Streptomyces natural product
Year first mentioned: 1970
Highest development stage: Approved
Development status: Approved
Chemical structure(s):
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Molecular weight: 454.47
Iso. SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)O)N
InChI Key: NSKGQURZWSPSBC-VVPCINPTSA-N
Can. SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@@H](CN)O2)O)O)N)O[C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O)O)O)N
InChI: InChI=1S/C17H34N4O10/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17/h4-17,22-27H,1-3,18-21H2/t4-,5+,6-,7-,8-,9+,10-,11-,12-,13-,14-,15-,16-,17+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/33042
Guide to Pharmacology: ribostamycin
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/44/12/44_12_1357/_pdf
  • https://www.jstage.jst.go.jp/article/antibiotics1968/23/3/23_3_155/_article

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