Micronomicin

Synonym(s): Sagamicin  |  gentamicin C2b

Class: Aminoglycoside

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome. Active against Gram-positive and Gram-negative bacteria
Description:	Micromonospora natural product. Approved in Japan for topical application
Year first mentioned:	1983
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H](CC[C@@H](CNC)O3)N)N)N)O
Isomeric SMILES:	C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H](CC[C@H](O3)CNC)N)N)N)O
InChI:	InChI=1S/C20H41N5O7/c1-20(28)8-29-19(14(27)17(20)25-3)32-16-12(23)6-11(22)15(13(16)26)31-18-10(21)5-4-9(30-18)7-24-2/h9-19,24-28H,4-8,21-23H2,1-3H3/t9-,10+,11-,12+,13-,14+,15+,16-,17+,18+,19+,20-/m0/s1
InChI Key:	DNYGXMICFMACRA-XHEDQWPISA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/3037206

External links:
Guide to Pharmacology:	micronomicin
Main Source:	https://www.jstage.jst.go.jp/article/antibiotics1968/36/2/36_2_125/_article