Compound ID | 1854

Update compound information

Micronomicin

Synonym(s): Sagamicin  |  gentamicin C2b

Class: Aminoglycoside

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome. Active against Gram-positive and Gram-negative bacteria
Description: Micromonospora natural product. Approved in Japan for topical application
Year first mentioned: 1983
Development status: Approved, off-patent
Chemical structure(s):
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Molecular weight: 463.57
Iso. SMILES: C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H](CC[C@H](O3)CNC)N)N)N)O
InChI Key: DNYGXMICFMACRA-XHEDQWPISA-N
Can. SMILES: C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H](CC[C@@H](CNC)O3)N)N)N)O
InChI: InChI=1S/C20H41N5O7/c1-20(28)8-29-19(14(27)17(20)25-3)32-16-12(23)6-11(22)15(13(16)26)31-18-10(21)5-4-9(30-18)7-24-2/h9-19,24-28H,4-8,21-23H2,1-3H3/t9-,10+,11-,12+,13-,14+,15+,16-,17+,18+,19+,20-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3037206
Guide to Pharmacology: micronomicin
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/36/2/36_2_125/_article

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