Compound ID | 186

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Lefamulin

Synonym(s): Xenleta  |  BC-3781

Class: Pleuromutilin

Spectrum of activity: Gram-positive
Details of activity: BC‑7013 is a topical pleuromutilin antibiotic ready against gram-positive infections
Institute where first reported: Nabriva Therapeutics, Austria
Year first mentioned: 2010
Highest developmental phase: Approved by FDA in 2019
Development status: Active
Chemical structure(s):
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Molecular weight: 507.73
Iso. SMILES: C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@@]1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CS[C@@H]4CC[C@H](C[C@H]4O)N)C
InChI Key: KPVIXBKIJXZQJX-FCEONZPQSA-N
Can. SMILES: C=C[C@]1(C)C[C@H]([C@]2(C)[C@H](C)CC[C@]3(CCC(=O)[C@@H]23)[C@@H](C)[C@@H]1O)OC(=O)CS[C@@H]4CC[C@H](C[C@H]4O)N
InChI: InChI=1S/C28H45NO5S/c1-6-26(4)14-22(34-23(32)15-35-21-8-7-18(29)13-20(21)31)27(5)16(2)9-11-28(17(3)25(26)33)12-10-19(30)24(27)28/h6,16-18,20-22,24-25,31,33H,1,7-15,29H2,2-5H3/t16-,17+,18-,20-,21-,22-,24+,25+,26-,27+,28+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/25185057
Guide to Pharmacology: BC-7013
Citations:
  • https://www.nabriva.com/Portals/_default/Skins/ProfessionalUs/pdfs/2009-%20antibacterial-spectrum-%20bc-3205.pdf
  • http://www.nabriva.com/programs/development/
  • https://www.nabriva.com/Portals/_default/Skins/ProfessionalUs/pdfs/extended-spectrum-pleuromutilins-mode-of-action-studies.pdf

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