Compound ID | 1863

Update compound information

Biapenem

Synonym(s): LJ C10,627

Class: Beta-lactam (carbapenem)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Carbapenems bind to all PBPs, with PBP2 and PBP4 as the highest-affinity targets.Carbapenems have a very broad spectrum incl. non-fermenters and are not hydrolysed by most beta-lactamases with exception of carbapenemases
Description: Semisynthetic, derived from thienamycin. Similar to imipenem but more stable against human renal dehydropeptidase-I. Available in Japan, Thailand, China and India
Year first mentioned: 1995
Highest developmental phase: Phase 1 (NCT01772836)
Development status: Active
Chemical structure(s):
Click here for structure editor
Molecular weight: 350.39
Iso. SMILES: C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1SC3CN4C=NC=[N+]4C3)C(=O)[O-])[C@@H](C)O
InChI Key: MRMBZHPJVKCOMA-YJFSRANCSA-N
Can. SMILES: C[C@@H]1[C@@H]2[C@@H]([C@@H](C)O)C(=O)N2C(=C1SC3CN4C=NC=[N+]4C3)C(=O)[O-]
InChI: InChI=1S/C15H18N4O4S/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)24-9-3-17-5-16-6-18(17)4-9/h5-11,20H,3-4H2,1-2H3/t7-,8-,10-,11-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/71339
Guide to Pharmacology: biapenem
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/8354307/
  • https://pubmed.ncbi.nlm.nih.gov/8626267/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944426/
  • https://pubmed.ncbi.nlm.nih.gov/12381221/

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.