Cefadroxil

Class: Beta-lactam (cephalosporin, first generation)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against Gram-positive bacteria and moderately against Enterobacteriaceae but high resistance rates in Enterobacteriaceae
Description:	Semisynthetic Cephalosporin, derived from Cephalosporin C. Oral application
Year first mentioned:	1967
Highest developmental phase:	Approved by FDA in 1987
Development status:	Approved

Chemical structure(s):
Canonical SMILES:	CC1=C(C(=O)O)N2C(=O)[C@H]([C@H]2SC1)NC(=O)[C@@H](C3=CC=C(C=C3)O)N
Isomeric SMILES:	CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)SC1)C(=O)O
InChI:	InChI=1S/C16H17N3O5S/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24)/t10-,11-,15-/m1/s1
InChI Key:	BOEGTKLJZSQCCD-UEKVPHQBSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/47965

External links:
Guide to Pharmacology:	cefadroxil
Main Source:	https://pubmed.ncbi.nlm.nih.gov/3542485/
Citations:	https://pubmed.ncbi.nlm.nih.gov/1337810/ https://pubmed.ncbi.nlm.nih.gov/21427400/ https://pubmed.ncbi.nlm.nih.gov/2292525/