Cephaloridine

Class: Beta-lactam (cephalosporin, first generation)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against Gram-positive bacteria and moderately against Enterobacteriaceae but high resistance rates in Enterobacteriaceae
Description:	Semisynthetic Cephalosporin, derived from Cephalosporin C
Year first mentioned:	1962
Highest developmental phase:	Approved
Development status:	Discontinued

Chemical structure(s):
Canonical SMILES:	C1=CC=[N+](C=C1)CC2=C(C(=O)[O-])N3C(=O)[C@H]([C@H]3SC2)NC(=O)CC4=CC=CS4
Isomeric SMILES:	C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CS3)C(=O)[O-])C[N+]4=CC=CC=C4
InChI:	InChI=1S/C19H17N3O4S2/c23-14(9-13-5-4-8-27-13)20-15-17(24)22-16(19(25)26)12(11-28-18(15)22)10-21-6-2-1-3-7-21/h1-8,15,18H,9-11H2,(H-,20,23,25,26)/t15-,18-/m1/s1
InChI Key:	CZTQZXZIADLWOZ-CRAIPNDOSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5773

External links:
Guide to Pharmacology:	cefaloridine
Main Source:	https://pubmed.ncbi.nlm.nih.gov/5359967/