Compound ID | 1880
Class: Beta-lactam (cephalosporin, first generation)
Spectrum of activity: | Gram-positive & Gram-negative |
Details of activity: | Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against Gram-positive bacteria and moderately against Enterobacteriaceae but high resistance rates in Enterobacteriaceae |
Description: | Semisynthetic Cephalosporin, derived from Cephalosporin C |
Year first mentioned: | 1962 |
Highest developmental phase: | Approved |
Development status: | Discontinued |
Chemical structure(s): | |
Canonical SMILES: | C1=CC=[N+](C=C1)CC2=C(C(=O)[O-])N3C(=O)[C@H]([C@H]3SC2)NC(=O)CC4=CC=CS4 |
Isomeric SMILES: | C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CS3)C(=O)[O-])C[N+]4=CC=CC=C4 |
InChI: | InChI=1S/C19H17N3O4S2/c23-14(9-13-5-4-8-27-13)20-15-17(24)22-16(19(25)26)12(11-28-18(15)22)10-21-6-2-1-3-7-21/h1-8,15,18H,9-11H2,(H-,20,23,25,26)/t15-,18-/m1/s1 |
InChI Key: | CZTQZXZIADLWOZ-CRAIPNDOSA-N |
Structure link: | https://pubchem.ncbi.nlm.nih.gov/compound/5773 |
External links: | |
Guide to Pharmacology: | cefaloridine |
Main Source: | https://pubmed.ncbi.nlm.nih.gov/5359967/ |