Compound ID | 1888

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Ceftezole

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. Binds to bacterial penicillin-binding proteins (PBP); PBP inhibitor
Target Pathogen: Active against Gram-positive bacteria and moderately against Enterobacteriaceae but high resistance rates in Enterobacteriaceae
Description: Semisynthetic Cephalosporin, derived from Cephalosporin C
Year first mentioned: 1976
Highest development stage: Approved
Development status: Approved
Chemical structure(s):
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Molecular weight: 440.48
Iso. SMILES: C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CN3C=NN=N3)C(=O)O)CSC4=NN=CS4
InChI Key: DZMVCVMFETWNIU-LDYMZIIASA-N
Can. SMILES: C(C(=O)N[C@@H]1C(=O)N2C(=C(CS[C@H]12)CSC3=NN=CS3)C(=O)O)N4C=NN=N4
InChI: InChI=1S/C13H12N8O4S3/c22-7(1-20-4-14-18-19-20)16-8-10(23)21-9(12(24)25)6(2-26-11(8)21)3-27-13-17-15-5-28-13/h4-5,8,11H,1-3H2,(H,16,22)(H,24,25)/t8-,11-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/65755
Guide to Pharmacology: ceftezole
Citation: https://journals.asm.org/doi/10.1128/AAC.10.1.1

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