Loracarbef

Synonym(s): Lorabid

Class: Beta-lactam (cephalosporin, second generation)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against Gram-positive bacteria and against many Enterobacteriaceae; it is less vulnerable to extended-spectum beta-lactamases (ESBL)
Description:	Synthetic Cephalosporin (carbacephem). Oral application
Institute where first reported:	King Pharmaceuticals
Year first mentioned:	1991
Highest developmental phase:	Approved by FDA in 1991
Development status:	Approved, off-patent , discontinued in many countries
Reason Dropped:	Discontinued in the US

Chemical structure(s):
Canonical SMILES:	C1=CC=C(C=C1)[C@H](C(=O)N[C@H]2[C@H]3CCC(=C(C(=O)O)N3C2=O)Cl)N
Isomeric SMILES:	C1CC(=C(N2[C@H]1[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)C(=O)O)Cl
InChI:	InChI=1S/C16H16ClN3O4/c17-9-6-7-10-12(15(22)20(10)13(9)16(23)24)19-14(21)11(18)8-4-2-1-3-5-8/h1-5,10-12H,6-7,18H2,(H,19,21)(H,23,24)/t10-,11-,12+/m1/s1
InChI Key:	JAPHQRWPEGVNBT-UTUOFQBUSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5284585

External links:
Guide to Pharmacology:	loracarbef
Main Source:	https://pubmed.ncbi.nlm.nih.gov/8453172/