Compound ID | 1902

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Cefminox

Synonym(s): MT 141

Class: Beta-lactam (cephalosporin, second generation)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against Gram-positive bacteria and against many Enterobacteriaceae and some anaerobes; it is less vulnerable to extended-spectum beta-lactamases (ESBL)
Description: Semisynthetic Cephalosporin, derived from Cephalosporin C
Year first mentioned: 1983
Development status: Approved, off-patent, discontinued in some countries
Chemical structure(s):
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Molecular weight: 519.58
Iso. SMILES: CN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@](C3=O)(NC(=O)CSC[C@H](C(=O)O)N)OC)SC2)C(=O)O
InChI Key: JSDXOWVAHXDYCU-VXSYNFHWSA-N
Can. SMILES: CN1C(=NN=N1)SCC2=C(C(=O)O)N3C(=O)[C@]([C@H]3SC2)(NC(=O)CSC[C@H](C(=O)O)N)OC
InChI: InChI=1S/C16H21N7O7S3/c1-22-15(19-20-21-22)33-4-7-3-32-14-16(30-2,13(29)23(14)10(7)12(27)28)18-9(24)6-31-5-8(17)11(25)26/h8,14H,3-6,17H2,1-2H3,(H,18,24)(H,25,26)(H,27,28)/t8-,14-,16+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/71141
Guide to Pharmacology: cefminox
Citation: https://pubmed.ncbi.nlm.nih.gov/25068396/

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