Ceftazidime

Class: Beta-lactam (cephalosporin, third generation)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against Gram-negative bacteria including Pseudomonas aeruginosa but vulnerable to extended-spectum beta-lactamases (ESBL)
Description:	Semisynthetic Cephalosporine, derived from Cephalosporin C. Often used in fixed combination with avibactam.
Year first mentioned:	1978
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	CC(C)(C(=O)O)O/N=C(/C1=CSC(=N1)N)\C(=O)N[C@@H]2C(=O)N3C(=C(C[N+]4=CC=CC=C4)CS[C@H]23)C(=O)[O-]
Isomeric SMILES:	CC(C)(C(=O)O)O/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)[O-]
InChI:	InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,18-/m1/s1
InChI Key:	ORFOPKXBNMVMKC-DWVKKRMSSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5481173

External links:
Guide to Pharmacology:	ceftazidime
Main Source:	https://pubmed.ncbi.nlm.nih.gov/3884319/
Citations:	https://pubmed.ncbi.nlm.nih.gov/11110047/ https://www.sciencedirect.com/science/article/pii/S2213716521001211?via%3Dihub