Cefpodoxime

Class: Beta-lactam (cephalosporin, third generation)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against Gram-positive bacteria and against many Enterobacteriaceae but vulnerable to extended-spectum beta-lactamases (ESBL)
Description:	Semisynthetic Cephalosporine, derived from Cephalosporin C. Oral application. Fixed combination with the beta-lactamase inhibitor ETX1317 in clinical development
Year first mentioned:	1980
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	COCC1=C(C(=O)O)N2C(=O)[C@H]([C@H]2SC1)NC(=O)/C(=N\OC)/C3=CSC(=N3)N
Isomeric SMILES:	COCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)O
InChI:	InChI=1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1
InChI Key:	WYUSVOMTXWRGEK-HBWVYFAYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/6335986

External links:
Guide to Pharmacology:	cefpodoxime
Main Source:	https://pubmed.ncbi.nlm.nih.gov/31029216/
Citations:	https://pubmed.ncbi.nlm.nih.gov/24214230/ https://pubmed.ncbi.nlm.nih.gov/34453533/