Cefepime

Class: Beta-lactam (cephalosporin, fourth generation)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against Gram-negative bacteria but vulnerable to higher levels of extended-spectum beta-lactamases (ESBL) and high resistance rates in Pseudomonas aeruginosa
Description:	Semisynthetic Cephalosporine, derived from Cephalosporin C. Fixed combination with several beta-lactamase inhibitors (taniborbactam, zidebactam, enmetazobactam, tazobactam)
Year first mentioned:	1982
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	C[N+]1(CCCC1)CC2=C(C(=O)[O-])N3C(=O)[C@H]([C@H]3SC2)NC(=O)/C(=N\OC)/C4=CSC(=N4)N
Isomeric SMILES:	C[N+]1(CCCC1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-]
InChI:	InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1
InChI Key:	HVFLCNVBZFFHBT-ZKDACBOMSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5479537

External links:
Guide to Pharmacology:	cefepime
Main Source:	https://pubmed.ncbi.nlm.nih.gov/8150771/
Citations:	https://linkinghub.elsevier.com/retrieve/pii/S1473309907701093 https://pubmed.ncbi.nlm.nih.gov/29166830/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502754/