Compound ID | 192

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MBX 2319, MBX2319, MBX-2319

Class: Efflux pump inhibitor

Spectrum of activity: Gram-negative
Details of activity: E. coli AcrB multidrug efflux pump
Institute where first reported: Microbiotix Inc, USA
Year first mentioned: 2013
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 409.55
Iso. SMILES: CC1(CC2=C(CO1)C(=NC(=C2C#N)SCCC3=CC=CC=C3)N4CCOCC4)C
InChI Key: CITLGGQQUFMBKB-UHFFFAOYSA-N
Can. SMILES: CC1(C)CC2=C(CO1)C(=NC(=C2C#N)SCCC3=CC=CC=C3)N4CCOCC4
InChI: InChI=1S/C23H27N3O2S/c1-23(2)14-18-19(15-24)22(29-13-8-17-6-4-3-5-7-17)25-21(20(18)16-28-23)26-9-11-27-12-10-26/h3-7H,8-14,16H2,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/1289417
Citations:
  • http://aac.asm.org/content/58/10/6224.full
  • http://aac.asm.org/content/58/2/722.full
  • http://aac.asm.org/content/early/2014/08/05/AAC.03283-14

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