Compound ID | 195

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Lascufloxacin

Synonym(s): KRP-AM1977

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: DNA synthesis inhibitor. Active against mutated GyrA and ParC; GyrA inhibitor; ParC inhibitor
Target Pathogen: Active against community-acquired bacterial pneumonia
Description: Synthetic compound
Institute where first reported: Kyorin Pharmaceuticals Co. Ltd, Japan
Year first mentioned: 2013
Highest developmental phase: Approved in Japan
Development status: Approved
Chemical structure(s):
Click here for structure editor
Molecular weight: 439.43
Iso. SMILES: COC1=C2C(=CC(=C1N3C[C@@H]([C@@H](C3)F)CNC4CC4)F)C(=O)C(=CN2CCF)C(=O)O
InChI Key: ZFIOCUITTUUVPV-MEDUHNTESA-N
Can. SMILES: COC1=C(C(=CC2=C1N(CCF)C=C(C2=O)C(=O)O)F)N3C[C@H](CNC4CC4)[C@@H](C3)F
InChI: InChI=1S/C21H24F3N3O4/c1-31-20-17-13(19(28)14(21(29)30)9-26(17)5-4-22)6-15(23)18(20)27-8-11(16(24)10-27)7-25-12-2-3-12/h6,9,11-12,16,25H,2-5,7-8,10H2,1H3,(H,29,30)/t11-,16+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/71528768
Guide to Pharmacology: lascufloxacin
Citations:
  • http://aac.asm.org/content/early/2017/03/14/AAC.00120-17.short
  • http://deals.bio/search/showOpportunityDetails?asset_id=2141
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913943/
  • http://www.kyorin-gr.co.jp/en/ir/rd/pipeline.shtml

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