Lascufloxacin

Synonym(s): KRP-AM1977

Class: Fluoroquinolone

Spectrum of activity:	Gram-positive
Details of activity:	Community-acquired bacterial pneumonia
Institute where first reported:	Kyorin Pharmaceuticals Co. Ltd, Japan
Year first mentioned:	2013
Development status:	Approved in Japan

Chemical structure(s):
Canonical SMILES:	COC1=C(C(=CC2=C1N(CCF)C=C(C2=O)C(=O)O)F)N3C[C@H](CNC4CC4)[C@@H](C3)F
Isomeric SMILES:	COC1=C2C(=CC(=C1N3C[C@@H]([C@@H](C3)F)CNC4CC4)F)C(=O)C(=CN2CCF)C(=O)O
InChI:	InChI=1S/C21H24F3N3O4/c1-31-20-17-13(19(28)14(21(29)30)9-26(17)5-4-22)6-15(23)18(20)27-8-11(16(24)10-27)7-25-12-2-3-12/h6,9,11-12,16,25H,2-5,7-8,10H2,1H3,(H,29,30)/t11-,16+/m0/s1
InChI Key:	ZFIOCUITTUUVPV-MEDUHNTESA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/71528768

External links:
Guide to Pharmacology:	lascufloxacin
Main Source:	http://www.kyorin-gr.co.jp/en/ir/rd/pipeline.shtml
Citations:	http://aac.asm.org/content/early/2017/03/14/AAC.00120-17.short http://deals.bio/search/showOpportunityDetails?asset_id=2141 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913943/