Compound ID | 1950

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Propicillin

Class: Beta-lactam (penicillin)

Spectrum of activity: Gram-positive
Details of activity: Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against Gram-positive bacteria, but vulnerable to penicillinases produced by staphylococci
Description: Semisynthetic penicillin, similar to penicillin V
Year first mentioned: 1961
Development status: Experimental
Chemical structure(s):
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Molecular weight: 378.44
Iso. SMILES: CCC(C(=O)N[C@H]1[C@@H]2N(C1=O)[C@H](C(S2)(C)C)C(=O)O)OC3=CC=CC=C3
InChI Key: HOCWPKXKMNXINF-XQERAMJGSA-N
Can. SMILES: CCC(C(=O)N[C@@H]1C(=O)N2[C@@H](C(=O)O)C(C)(C)S[C@H]12)OC3=CC=CC=C3
InChI: InChI=1S/C18H22N2O5S/c1-4-11(25-10-8-6-5-7-9-10)14(21)19-12-15(22)20-13(17(23)24)18(2,3)26-16(12)20/h5-9,11-13,16H,4H2,1-3H3,(H,19,21)(H,23,24)/t11?,12-,13+,16-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/92879
Citation: https://pubmed.ncbi.nlm.nih.gov/7194084/

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