Compound ID | 1957

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Ledaborbactam

Synonym(s): VNRX-7145

Class: Beta-lactamase inhibitor

Agent Type: Synthetic; Small molecule; Direct acting; Antibiotic adjuvant;
Mechanism of action: Binds to beta-lactamases with a focus on serine enzymes (class A, C, D). Fixed combination with ceftibuten
Combined with other compounds: Yes
Description: Synthetic compound; in clinical development in fixed combination with ceftibuten; prodrug VNRX-5236 etzadroxil for oral application; a boron-based antibiotic
Institute where first reported: VenatoRx Pharmaceuticals
Year first mentioned: 2017
Highest development stage: Phase 1 (as of 2022)
Development status: Active
Chemical structure(s):
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Molecular weight: 263.05
Iso. SMILES: B1([C@H](CC2=C(O1)C(=CC=C2)C(=O)O)NC(=O)CC)O
InChI Key: QAGGLFCWUVSERJ-VIFPVBQESA-N
Can. SMILES: CCC(=O)N[C@H]1CC2=CC=CC(=C2OB1O)C(=O)O
InChI: InChI=1S/C12H14BNO5/c1-2-10(15)14-9-6-7-4-3-5-8(12(16)17)11(7)19-13(9)18/h3-5,9,18H,2,6H2,1H3,(H,14,15)(H,16,17)/t9-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/#query=Ledaborbactam
Guide to Pharmacology: ledaborbactam
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284453/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311649/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765315/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311649/

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