Ledaborbactam

Synonym(s): VNRX-7145

Class: Beta-lactamase inhibitor (boron-based)

Details of activity:	Binds to beta-lactamases with a focus on serine enzymes (class A, C, D). Fixed combination with ceftibuten
Combined with other compounds:	Yes
Description:	Synthetic compound. In clinical development in fixed combination with ceftibuten. Prodrug VNRX-5236 etzadroxil for oral application
Institute where first reported:	VenatoRx Pharmaceuticals
Year first mentioned:	2017
Highest developmental phase:	Phase 1 (as of 2022)
Development status:	Active (as of 2022)

Chemical structure(s):
Canonical SMILES:	CCC(=O)N[C@H]1CC2=CC=CC(=C2OB1O)C(=O)O
Isomeric SMILES:	B1([C@H](CC2=C(O1)C(=CC=C2)C(=O)O)NC(=O)CC)O
InChI:	InChI=1S/C12H14BNO5/c1-2-10(15)14-9-6-7-4-3-5-8(12(16)17)11(7)19-13(9)18/h3-5,9,18H,2,6H2,1H3,(H,14,15)(H,16,17)/t9-/m0/s1
InChI Key:	QAGGLFCWUVSERJ-VIFPVBQESA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/#query=Ledaborbactam

External links:
Guide to Pharmacology:	ledaborbactam
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311649/
Citations:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284453/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311649/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765315/