Aztreonam

Class: Beta-lactam (monobactam)

Spectrum of activity:	Gram-negative
Details of activity:	Binds to bacterial penicillin-binding proteins (PBP) with high affinity for PBP 3 and mild affinity for PBP 1a and interferes with bacterial cell wall integrity and synthesis. It is active against gram-negative bacteria including many metallo-beta-lactamase producing strains.
Description:	Synthetic monobactam. Intravenous application. Aztreonam lysine is used as a nebuliser solution for suppressive therapy of chronic pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis. Aztreonam is studied in combination with the beta-lactamase inhibitor avibactam
Year first mentioned:	1979
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	C[C@H]1[C@@H](C(=O)N1S(=O)(=O)O)NC(=O)/C(=N\OC(C)(C)C(=O)O)/C2=CSC(=N2)N
Isomeric SMILES:	C[C@H]1[C@@H](C(=O)N1S(=O)(=O)O)NC(=O)/C(=N\OC(C)(C)C(=O)O)/C2=CSC(=N2)N
InChI:	InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1
InChI Key:	WZPBZJONDBGPKJ-VEHQQRBSSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5742832

External links:
Guide to Pharmacology:	aztreonam
Citation:	https://www.mdpi.com/2079-6382/10/8/1012/htm