Oximonam

Class: Beta-lactam (monobactam, oxymazins)

Spectrum of activity:	Gram-negative
Details of activity:	Binds to bacterial penicillin-binding proteins (PBP) with high affinity for PBP 3 and mild affinity for PBP 1a and interferes with bacterial cell wall integrity and synthesis. It is active against gram-negative bacteria including many metallo-beta-lactamase producing strains.
Description:	Synthetic monobactam
Year first mentioned:	1985
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	C[C@H]1[C@@H](C(=O)N1OCC(=O)O)NC(=O)/C(=N\OC)/C2=CSC(=N2)N
Isomeric SMILES:	C[C@H]1[C@@H](C(=O)N1OCC(=O)O)NC(=O)/C(=N\OC)/C2=CSC(=N2)N
InChI:	InChI=1S/C12H15N5O6S/c1-5-8(11(21)17(5)23-3-7(18)19)15-10(20)9(16-22-2)6-4-24-12(13)14-6/h4-5,8H,3H2,1-2H3,(H2,13,14)(H,15,20)(H,18,19)/b16-9-/t5-,8-/m0/s1
InChI Key:	FJKOYBHMMTVFHK-TWYJFGHKSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/9690097

External links:
Guide to Pharmacology:	oximonam
Main Source:	http://cmdr.ubc.ca/bobh/wp-content/uploads/2017/01/BC-Schurek-2012.pdf
Citations:	https://academic.oup.com/jac/article/17/3/303/701792?login=true https://pubmed.ncbi.nlm.nih.gov/3360965/